{"id":1498,"date":"2023-02-14T17:45:57","date_gmt":"2023-02-14T15:45:57","guid":{"rendered":"https:\/\/psy.artamax.eu\/?page_id=1498"},"modified":"2025-06-27T17:05:53","modified_gmt":"2025-06-27T16:05:53","slug":"prof-dr-marlene-bartos-laboratory-of-systems-cellular-neuroscience","status":"publish","type":"page","link":"https:\/\/physiology-freiburg.de\/de\/prof-dr-marlene-bartos-laboratory-of-systems-cellular-neuroscience\/","title":{"rendered":"Prof. Dr. Marlene Bartos &#8211; Labor f\u00fcr System- und Zellul\u00e4re Neurowissenschaften"},"content":{"rendered":"<section class=\"wpb-content-wrapper\"><section class=\"l-section wpb_row us_custom_0d15be52 height_medium with_img\"><div class=\"l-section-img\" style=\"background-image: url(https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/01\/title-bg2.jpg);background-repeat: repeat-x;\" data-img-width=\"1980\" data-img-height=\"347\"><\/div><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column us_custom_c3caa8b2 has_text_color\"><div class=\"wpb_wrapper\"><h1 style=\"text-align: center;\">Labor f\u00fcr System- und Zellul\u00e4re Neurowissenschaften<\/h1>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row height_small\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_top type_default stacking_default\" style=\"--additional-gap:1rem;\"><div class=\"vc_col-sm-3\/5 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><h2>Prof. Marlene Bartos &#8211; Forschungsgruppe Systemische und zellul\u00e4re Neurowissenschaften<\/h2>\n<p>Wir wollen verstehen, wie die dendritische Integration der Aktivit\u00e4t in den Hauptzellen und GABAergen Interneuronen die Funktion der Mikroschaltkreise und das Verhalten beeinflusst.<\/p>\n<p><a href=\"https:\/\/www.physiologie.uni-freiburg.de\/neural-networks\/cv-bartos\" target=\"_blank\" rel=\"noopener\"><strong>Curriculum Vitae<\/strong><\/a><\/p>\n<\/div><\/div><\/div><\/div><\/div><div class=\"vc_col-sm-2\/5 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"w-image align_none\"><a href=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/dr-marlene-bartos.jpg\" ref=\"magnificPopup\" aria-label=\"Link\" class=\"w-image-h\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"533\" src=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/dr-marlene-bartos.jpg\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/dr-marlene-bartos.jpg 800w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/dr-marlene-bartos-600x400.jpg 600w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/dr-marlene-bartos-300x200.jpg 300w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/a><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row height_small\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_top type_default stacking_default\" style=\"--additional-gap:1rem;\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><h2>Forschung<\/h2>\n<p>Ein grundlegendes und faszinierendes Merkmal des S\u00e4ugetiergehirns ist seine F\u00e4higkeit, neue Informationen aufzunehmen und zu speichern. Unsere Forschung konzentriert sich darauf, wie das Ged\u00e4chtnis in neuronalen Netzwerken repr\u00e4sentiert wird. Unser Ziel ist es, die Mechanismen zu verstehen, die dem Entstehen von lernassoziierten aktiven Zellpopulationen (Zellverb\u00e4nden) zugrunde liegen, die neue Erinnerungen repr\u00e4sentieren. Wir konzentrieren uns auf den Gyrus dentatus (DG) von Nagetieren, die Input-Region des Hippocampus, von der bekannt ist, dass sie bei vielen Spezies, einschlie\u00dflich Menschen und Nagetieren, funktionell entscheidend f\u00fcr den Erwerb neuer Erinnerungen ist. Unsere Arbeit hat die zellul\u00e4ren und synaptischen Eigenschaften von Neuronen und Synapsen im Schaltkreis der DG sowie die Mechanismen gekl\u00e4rt, die der Synchronisierung neuronaler Netzwerke f\u00fcr die Codierung von Informationen zugrunde liegen. Wir haben die zellul\u00e4ren, synaptischen und Netzwerkmechanismen untersucht, die f\u00fcr die Entwicklung neuronaler Netzwerke wichtig sind, wobei wir uns auf GABAerge inhibitorische Zellen konzentriert haben.<\/p>\n<p><strong>Unsere wichtigsten Forschungsthemen sind: <\/strong><\/p>\n<ol>\n<li>um die r\u00e4umliche und zeitliche Entstehung von lernassoziierten Zellverb\u00e4nden zu verstehen, die neue Erinnerungen repr\u00e4sentieren.<\/li>\n<li>die Art und Bedeutung der wichtigsten funktionellen (zellul\u00e4ren, synaptischen, plastischen) und strukturellen Ver\u00e4nderungen, die der Bildung von Zellverb\u00e4nden zugrunde liegen, zu beschreiben.<\/li>\n<li>die funktionellen und dynamischen Merkmale der synaptischen Kommunikation zwischen Zellen und ihre Rolle bei der Informationsverarbeitung in kortikalen Mikroschaltkreisen zu verstehen.<\/li>\n<li>die Rolle der sehr unterschiedlichen GABAergen Zellpopulation bei der Funktion neuronaler Netzwerke und der Bildung von Zellverb\u00e4nden zu ermitteln.<\/li>\n<li>um die Fehlfunktion zellul\u00e4rer Komponenten in spezifischen Mausmodellen zu untersuchen, die neuronalen Erkrankungen zugrunde liegen.<\/li>\n<\/ol>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row us_custom_8535c5f4 height_small\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_top type_default stacking_default\" style=\"--additional-gap:1rem;\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><h2>Techniques<\/h2>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row us_custom_8535c5f4 height_medium\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_top type_default stacking_default\" style=\"--additional-gap:1rem;\"><div class=\"vc_col-sm-3 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"w-image align_none\"><div class=\"w-image-h\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"533\" src=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/bartos1.jpg\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/bartos1.jpg 800w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/bartos1-600x400.jpg 600w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/bartos1-300x200.jpg 300w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/div><\/div><\/div><\/div><\/div><div class=\"vc_col-sm-3 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><div style=\"width: 288px;\" class=\"wp-video\"><video class=\"wp-video-shortcode\" id=\"video-1498-1\" width=\"288\" height=\"240\" loop autoplay preload=\"metadata\" controls=\"controls\"><source type=\"video\/mp4\" src=\"https:\/\/psy.artamax.eu\/wp-content\/uploads\/2023\/02\/1Media1.mp4?_=1\" \/><a href=\"https:\/\/psy.artamax.eu\/wp-content\/uploads\/2023\/02\/1Media1.mp4\">https:\/\/psy.artamax.eu\/wp-content\/uploads\/2023\/02\/1Media1.mp4<\/a><\/video><\/div>\n<\/div><\/div><\/div><\/div><\/div><div class=\"vc_col-sm-3 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><div style=\"width: 240px;\" class=\"wp-video\"><video class=\"wp-video-shortcode\" id=\"video-1498-2\" width=\"240\" height=\"176\" loop autoplay preload=\"metadata\" controls=\"controls\"><source type=\"video\/mp4\" src=\"https:\/\/psy.artamax.eu\/wp-content\/uploads\/2023\/02\/1Media2.mp4?_=2\" \/><a href=\"https:\/\/psy.artamax.eu\/wp-content\/uploads\/2023\/02\/1Media2.mp4\">https:\/\/psy.artamax.eu\/wp-content\/uploads\/2023\/02\/1Media2.mp4<\/a><\/video><\/div>\n<\/div><\/div><\/div><\/div><\/div><div class=\"vc_col-sm-3 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><div style=\"width: 272px;\" class=\"wp-video\"><video class=\"wp-video-shortcode\" id=\"video-1498-3\" width=\"272\" height=\"192\" loop autoplay preload=\"metadata\" controls=\"controls\"><source type=\"video\/mp4\" src=\"https:\/\/psy.artamax.eu\/wp-content\/uploads\/2023\/02\/1Media3.mp4?_=3\" \/><a href=\"https:\/\/psy.artamax.eu\/wp-content\/uploads\/2023\/02\/1Media3.mp4\">https:\/\/psy.artamax.eu\/wp-content\/uploads\/2023\/02\/1Media3.mp4<\/a><\/video><\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row height_small\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_top type_default stacking_default\" style=\"--additional-gap:1rem;\"><div class=\"vc_col-sm-6 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><h3><strong>Miniskop-Bildgebung<\/strong><\/h3>\n<p>Wir verwenden Inscopix nVoke-Systeme zur Abbildung von Ca<sup>2+<\/sup>-Signalen mit einer zellul\u00e4ren Aufl\u00f6sung von einem Photon in Kombination mit optogenetischer Stimulation im selben Sichtfeld, um die Zellaktivit\u00e4t und die Schaltkreise im Hippocampus und im pr\u00e4frontalen Kortex bei frei verhaltenden Tieren zu untersuchen.<\/p>\n<p>Unser Ziel ist es, die longitudinale Beteiligung von Zellensembles im pr\u00e4frontalen Kortex und in Unterregionen des Hippocampus w\u00e4hrend des Arbeitsged\u00e4chtnisses, des sozialen Ged\u00e4chtnisses und der r\u00e4umlichen Kodierung\/Diskriminierung zu verstehen. Wir wollen die Schaltkreisdynamik des Lernens, der Ged\u00e4chtniskonsolidierung und des Abrufs von Kurzzeit- und Fernged\u00e4chtnis verstehen und so den Beitrag verschiedener Zelltypen und Neuromodulatoren zur Ged\u00e4chtnisrepr\u00e4sentation im Gehirn entschl\u00fcsseln.<\/p>\n<\/div><\/div><\/div><\/div><\/div><div class=\"vc_col-sm-6 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"g-cols wpb_row via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-6 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"w-image align_none\"><a href=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/miniscope-imaging-1.jpg\" ref=\"magnificPopup\" aria-label=\"Link\" class=\"w-image-h\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"298\" src=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/miniscope-imaging-1-300x298.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" srcset=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/miniscope-imaging-1-300x298.jpg 300w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/miniscope-imaging-1.jpg 391w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/div><div class=\"w-separator size_small\"><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Das linke Bild zeigt einen genetisch kodierten Calcium-Indikator (gr\u00fcn), der in den Hippocampus-Bereichen CA1 exprimiert wird (Ma\u00dfstabsleiste = 100 um, rot ist die Gegenf\u00e4rbung).<\/p>\n<\/div><\/div><\/div><\/div><\/div><div class=\"vc_col-sm-6 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"w-image align_none\"><a href=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/miniscope-imaging-2.jpg\" ref=\"magnificPopup\" aria-label=\"Link\" class=\"w-image-h\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"298\" src=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/miniscope-imaging-2-300x298.jpg\" class=\"attachment-thumbnail size-thumbnail\" alt=\"\" srcset=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/miniscope-imaging-2-300x298.jpg 300w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/miniscope-imaging-2.jpg 391w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/div><div class=\"w-separator size_small\"><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Das rechte Bild ist eine Projektion des Blickfelds einer Miniskopkamera, wobei die fluoreszierenden Zellk\u00f6rper als Eiformen im Graustufenbild erscheinen. Die Helligkeit ist proportional zur Zellaktivit\u00e4t.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row height_small\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_top type_default stacking_default\" style=\"--additional-gap:1rem;\"><div class=\"vc_col-sm-6 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><h3><strong>2-Photonen-Populationsbildgebung<\/strong><\/h3>\n<p>Wir untersuchen die Entstehung und Aktivit\u00e4t von Ged\u00e4chtnis-Engrammen im Hippocampus bei wachen, sich verhaltenden Tieren mit Hilfe der Zwei-Photonen-Kalzium-Bildgebung im Gyrus dentatus und den Hippocampus-Unterfeldern CA1-3 von M\u00e4usen, deren Kopf fixiert ist. M\u00e4use f\u00fchren kontextbezogene Unterscheidungsaufgaben in einer virtuellen Umgebung durch, die auf Bildschirmen um sie herum angezeigt wird.<\/p>\n<p>Wir untersuchen, wie Hauptneuronen in verschiedenen Unterfeldern des Hippocampus r\u00e4umliche Kontexte repr\u00e4sentieren, wie sich diese Repr\u00e4sentationen mit zunehmender Vertrautheit entwickeln, wie lokale Mikroschaltkreise der Bildung neuronaler Ensembles zugrunde liegen und wie die Aktivit\u00e4t lokaler inhibitorischer Schaltkreise durch sensorische Erfahrung und Neuheitserkennung moduliert wird.<\/p>\n<p>Unser Ziel ist es zu entschl\u00fcsseln, wie neuronale Schaltkreise im Hippocampus die Inhalte komplexer episodischer Erinnerungen speichern und abrufen.<\/p>\n<p>Das Video zeigt eine Maus, die auf einer Syropor-Kugel l\u00e4uft, die die Navigation durch die auf den Computermonitoren angezeigte virtuelle Umgebung steuert.<\/p>\n<\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><div style=\"width: 720px;\" class=\"wp-video\"><video class=\"wp-video-shortcode\" id=\"video-1498-4\" width=\"720\" height=\"406\" loop autoplay preload=\"metadata\" controls=\"controls\"><source type=\"video\/mp4\" src=\"\/wp-content\/uploads\/2023\/02\/MOESM3_ESM.mp4?_=4\" \/><a href=\"\/wp-content\/uploads\/2023\/02\/MOESM3_ESM.mp4\">\/wp-content\/uploads\/2023\/02\/MOESM3_ESM.mp4<\/a><\/video><\/div>\n<\/div><\/div><\/div><\/div><\/div><div class=\"vc_col-sm-6 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"w-image align_none\"><a href=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/2-photon-population-imaging.jpg\" ref=\"magnificPopup\" aria-label=\"Link\" class=\"w-image-h\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"500\" src=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/2-photon-population-imaging.jpg\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/2-photon-population-imaging.jpg 1024w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/2-photon-population-imaging-600x293.jpg 600w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/2-photon-population-imaging-300x146.jpg 300w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row height_small\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_top type_default stacking_default\" style=\"--additional-gap:1rem;\"><div class=\"vc_col-sm-6 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><h3><strong>Konnektivit\u00e4t der neuronalen Mikroschaltkreise<\/strong><\/h3>\n<p>Um die Funktion einer bestimmten Nervenzelle (eines bestimmten Typs) genau beurteilen zu k\u00f6nnen, ist es unerl\u00e4sslich, die pr\u00e4- und postsynaptischen Partner dieser Zelle (dieses Typs) zu erfassen. Wir verwenden retrograde Marker wie die mit Fluoreszenzfarbstoff konjugierte Cholera-Toxin-Beta-Untereinheit (CTB) sowie retrograde &amp; anterograde Adeno-Assoziierte Viren (AAV) verschiedener Serotypen und Canine Adeno-Virus Typ 2 (CAV2) zur fluoreszierenden Markierung neuronaler Populationen. Weitere Spezifit\u00e4t erhalten wir durch die Verwendung selektiver viraler Promotoren oder Cre-Recombinase-exprimierender transgener M\u00e4use, um spezifische neuronale Subpopulationen auf der Grundlage ihrer neurochemischen Identit\u00e4t oder ihres postsynaptischen Zielbereichs zu markieren. Dar\u00fcber hinaus k\u00f6nnen diese Viren auch zur gleichzeitigen Expression genetisch kodierter lichtgesteuerter Ionenkan\u00e4le (Opsine) verwendet werden, um diese verschiedenen Zelltypen entweder in vivo oder in vitro zu aktivieren oder zu hemmen, was eine Analyse sowohl der strukturellen als auch der funktionellen Konnektivit\u00e4t erm\u00f6glicht. Wir untersuchen auch die pr\u00e4synaptischen Eing\u00e4nge zu den verschiedenen Zelltypen mit Hilfe der monosynaptischen Tollwutvirusverfolgung, die es uns erm\u00f6glicht, neuronale subtypabh\u00e4ngige Konnektivit\u00e4tsmotive zwischen identifizierten pr\u00e4- und postsynaptischen Neuronen im Gehirn zu bewerten.<\/p>\n<p>Injektion eines cre-abh\u00e4ngigen Virus, das GFP (gr\u00fcn) exprimiert, in den Gyrus dentatus einer transgenen Maus, die cre unter dem Somatostatin-Promotor exprimiert. Post-hoc-Immunmarkierung f\u00fcr Calbindin (rot) und mGluR1a (blau) wurde ebenfalls durchgef\u00fchrt.<\/p>\n<\/div><\/div><\/div><\/div><\/div><div class=\"vc_col-sm-6 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"w-image align_none\"><a href=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/connectivity-of-neuronal-microcircuits.jpg\" ref=\"magnificPopup\" aria-label=\"Link\" class=\"w-image-h\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"500\" src=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/connectivity-of-neuronal-microcircuits.jpg\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/connectivity-of-neuronal-microcircuits.jpg 1024w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/connectivity-of-neuronal-microcircuits-600x293.jpg 600w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/connectivity-of-neuronal-microcircuits-300x146.jpg 300w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/div><div class=\"w-separator size_small\"><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Left image shows the Hippocampus of a transgenic mouse that expressed cre under the Somatostatin promoter after injection of a cre-dependent, GFP-expressing virus into the Dentate Gyrus (green). Post-hoc immunolabelling for Calbindin (Ca<sup>2+<\/sup> binding protein; red) and mGluR1\u03b1 (metabotropic Glutamate receptor; blue) was also performed. An enlarged view is shown on the right.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row height_small\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_top type_default stacking_default\" style=\"--additional-gap:1rem;\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><h3><strong>Aufzeichnung mit einer Silizium-Sonde<\/strong><\/h3>\n<p>Wir untersuchen die Dynamik des neuronalen Netzwerks mit Hilfe gro\u00df angelegter Einzelaufzeichnungen von am Kopf fixierten M\u00e4usen, die in virtuellen Umgebungen navigieren (A). Mit mehrschenkligen Silizium-Sonden und Lichtleiter-Implantaten untersuchen wir die Aktivit\u00e4t von Hauptzellen des Hippocampus und optogenetisch identifizierten Interneuronen (B). Mit linearen Silizium-Sonden untersuchen wir dar\u00fcber hinaus die Aktivit\u00e4t von Neuronen in verschiedenen Bereichen des pr\u00e4frontalen Kortex bei wachen M\u00e4usen (C). Unser Ziel ist es zu verstehen, wie neuronale Ensembles in Hippocampus und Kortex dynamisch Verhaltensvariablen kodieren.<\/p>\n<\/div><\/div><div class=\"w-image align_none\"><a href=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/single-unit-silicon-probe-recordings.jpg\" ref=\"magnificPopup\" aria-label=\"Link\" class=\"w-image-h\"><img loading=\"lazy\" decoding=\"async\" width=\"1440\" height=\"400\" src=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/single-unit-silicon-probe-recordings.jpg\" class=\"attachment-full size-full\" alt=\"\" srcset=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/single-unit-silicon-probe-recordings.jpg 1440w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/single-unit-silicon-probe-recordings-600x167.jpg 600w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/single-unit-silicon-probe-recordings-1024x284.jpg 1024w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/single-unit-silicon-probe-recordings-300x83.jpg 300w\" sizes=\"auto, (max-width: 1440px) 100vw, 1440px\" \/><\/a><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row height_small\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_top type_default stacking_default\" style=\"--additional-gap:1rem;\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><h3><strong>Interneuronale Vielfalt<\/strong><\/h3>\n<p>In den letzten 25 Jahren wurden zahlreiche Studien \u00fcber die neurochemischen, morphologischen, physiologischen und pharmakologischen Eigenschaften von Interneuronen durchgef\u00fchrt, die zur Identifizierung einer Vielzahl von anatomisch und funktionell unterschiedlichen GABAergen Interneurontypen f\u00fchrten. Diese Studien zeigten, dass der Zellk\u00f6rper, das axoninitiale Segment und die dendritischen Bereiche von Pyramidenzellen und Interneuronen von unterschiedlichen Interneuronentypen gesteuert werden (Markram et al., 2004; Bartos et al., 2014), was darauf hindeutet, dass kompartimentspezifische Rechenoperationen auf der Ebene einzelner Zellen von spezialisierten hemmenden Zellen gesteuert werden. Die Diversit\u00e4t der Interneuronen wurde haupts\u00e4chlich in den CA1-3 des Hippocampus und in neokortikalen Arealen untersucht. Wir konzentrieren unsere Arbeit auf den Gyrus dentatus, das Eingangstor des Hippocampus, und verwenden dazu die intrazellul\u00e4re Markierung von Zellen in Schnittpr\u00e4paraten mit anschlie\u00dfender Antik\u00f6rpermarkierung, konfokaler und Elektronenmikroskopie. Dar\u00fcber hinaus markieren wir bei transgenen M\u00e4usen mit viraler Expression lokale und weitreichend projizierende Interneurontypen.<\/p>\n<p>A) Morphologische Rekonstruktionen und elektrophysiologische Reaktionen auf Strominjektion f\u00fcr zwei verschiedene Arten von Somatostatin-exprimierenden Interneuronen mit Zellk\u00f6rpern im Hilus. B) Die Injektion eines cre-abh\u00e4ngigen Virus in SOM-cre-M\u00e4use markiert Hilus-Neuronen mit GFP (gr\u00fcn), und die Axone k\u00f6nnen zu Zielgebieten wie dem medialen Septum (unteres Feld) verfolgt werden. DAPI (blau) ist eine zellul\u00e4re Gegenf\u00e4rbung. Die Immunf\u00e4rbung f\u00fcr Somatostatin wurde zur Best\u00e4tigung des Zelltyps verwendet (oberes rechtes Feld). C) In das mediale Septum injizierte Retrobeads (rot markiert) best\u00e4tigen, dass die GFP-exprimierenden Axone von den Hilar-Zellen stammen. D) Beispielbilder von intrazellul\u00e4r gef\u00fcllten, Retrobead-markierten Hilar, Somatostatin-exprimierenden Interneuronen.<\/p>\n<\/div><\/div><div class=\"w-image align_none\"><a href=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/interneuron-diversity.jpg\" ref=\"magnificPopup\" aria-label=\"Link\" class=\"w-image-h\"><img loading=\"lazy\" decoding=\"async\" width=\"1440\" height=\"540\" src=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/interneuron-diversity.jpg\" class=\"attachment-full size-full\" alt=\"\" srcset=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/interneuron-diversity.jpg 1440w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/interneuron-diversity-600x225.jpg 600w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/interneuron-diversity-1024x384.jpg 1024w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/interneuron-diversity-300x113.jpg 300w\" sizes=\"auto, (max-width: 1440px) 100vw, 1440px\" \/><\/a><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row height_small\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_top type_default stacking_default\" style=\"--additional-gap:1rem;\"><div class=\"vc_col-sm-6 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><h3><strong>Plastizit\u00e4t <\/strong><\/h3>\n<p>GABAerge inhibitorische Interneuronen (INs) im Kortex von S\u00e4ugetieren zeichnen sich durch eine gro\u00dfe Vielfalt aus, die auf ihren molekularen, morphologischen und physiologischen Eigenschaften beruht. Es wird angenommen, dass die verschiedenen IN-Typen die Aktivit\u00e4t und Erregbarkeit ihrer Zielzellen auf kompartimentspezifische Weise steuern. J\u00fcngste Untersuchungen in unserer Gruppe deuten darauf hin, dass einige IN-Typen unter der Kontrolle der Plastizit\u00e4t stehen. In unserer Forschung konzentrieren wir uns auf die Mechanismen, die eine langfristige Verst\u00e4rkung oder Abschw\u00e4chung glutamaterger synaptischer Eing\u00e4nge auf Parvalbumin (PV) und Somatostatin (SOM)-exprimierende Interneuronen (PVIs bzw. SOMIs) erm\u00f6glichen. Wir wollen verstehen, wie diese synaptischen plastischen Ver\u00e4nderungen zum Gesamtzustand der neuronalen Netzwerkaktivit\u00e4t, in die diese INs eingebettet sind, zur Informationsverarbeitung und zum Verhaltensergebnis beitragen. Um diese Ziele zu erreichen, verwenden wir einen multidisziplin\u00e4ren Ansatz, der In-vitro-Ganzzellaufnahmen, shRNA zur Beeinflussung der Induktion synaptischer Plastizit\u00e4t, In-vivo-Einzelzellaufnahmen von optotagged IN-Typen und Verhaltensanalysen kombiniert. Wir konzentrieren diese Untersuchungen auf PVIs und SOMIs des Gyrus dentatus bei M\u00e4usen. Wir haben zuvor gezeigt, dass Moosfasersynapsen, die von K\u00f6rnerzellen des Gyrus dentatus ausgehen, Langzeitpotenzierung (LTP) auf beide IN-Typen vermitteln. Diese Form der LTP h\u00e4ngt von der Aktivierung metabotroper Glutamatrezeptoren der Gruppe I ab (Sambandan et al., J Neurosci 2010; Hainmueller &amp; Bartos, PNAS USA 2014; Yuan et al, eLife 2017).<\/p>\n<\/div><\/div><\/div><\/div><\/div><div class=\"vc_col-sm-6 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"w-image align_none\"><a href=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/Plasticity-e1677505444995.jpg\" ref=\"magnificPopup\" aria-label=\"Link\" class=\"w-image-h\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"533\" src=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/02\/Plasticity-e1677505444995.jpg\" class=\"attachment-large size-large\" alt=\"\" \/><\/a><\/div><div class=\"w-separator size_small\"><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Bild oben links: kombinierte Immunmarkierung f\u00fcr Parvalbumin (PV; gr\u00fcn) und Somatostatin (SOM; rot) im Gyrus Dentatus. Bild oben rechts: Beispiele f\u00fcr Immunmarkierungen f\u00fcr den metabotropen Glutamatrezeptor Typ 1 (mGluR1; gelb), der von SOM-Interneuronen (rot) exprimiert wird, und f\u00fcr den metabotropen Glutamatrezeptor Typ 5 (mGluR5; magenta), der von PV-Interneuronen (gr\u00fcn) exprimiert wird. Das untere Feld zeigt die Morphologie und Elektrophysiologie einer gepaarten Aufzeichnung zwischen einer K\u00f6rnerzelle und einem PV-exprimierenden Interneuron im Gyrus dentatus w\u00e4hrend eines assoziativen Burst-Frequenz-Stimulationsprotokolls, das eine lang anhaltende Verst\u00e4rkung der Erregung des Interneurons bewirkt. Dies wird dann durch DCG-IV r\u00fcckg\u00e4ngig gemacht.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row us_custom_8535c5f4 height_small\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_top type_default stacking_default\" style=\"--additional-gap:1rem;\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><h2>Ausgew\u00e4hlte Ver\u00f6ffentlichungen<\/h2>\n<\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p><strong>Originalarbeiten<\/strong><\/p>\n<\/div><\/div><div class=\"w-tabs layout_ver navwidth_auto navpos_left style_default switch_click has_scrolling\" style=\"--sections-title-size:1em\"><div class=\"w-tabs-list items_4 align_none\"><div class=\"w-tabs-list-h\"><button class=\"w-tabs-item active\" aria-controls=\"content-faa8\"><span class=\"w-tabs-item-title\">2021 &#8211; 2023<\/span><\/button><button class=\"w-tabs-item\" aria-controls=\"content-be7a\"><span class=\"w-tabs-item-title\">2016 &#8211; 2020<\/span><\/button><button class=\"w-tabs-item\" aria-controls=\"content-b1e4\"><span class=\"w-tabs-item-title\">2011 &#8211; 2015<\/span><\/button><button class=\"w-tabs-item\" aria-controls=\"content-x562\"><span class=\"w-tabs-item-title\">2006 &#8211; 2010<\/span><\/button><\/div><\/div><div class=\"w-tabs-sections titles-align_none icon_chevron cpos_right\"><div class=\"w-tabs-section active\" id=\"faa8\"><button aria-controls=\"content-faa8\" class=\"w-tabs-section-header active\"><div class=\"w-tabs-section-title\">2021 &#8211; 2023<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-faa8\" aria-expanded=\"true\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><div id=\"content-t1e2\" class=\"w-tabs-section-content\" aria-expanded=\"true\">\n<div class=\"w-tabs-section-content-h i-cf\">\n<div class=\"wpb_text_column\">\n<div class=\"wpb_wrapper\">\n<p>2025<\/p>\n<div class=\"docsum-wrap\">\n<ul>\n<li class=\"docsum-content\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40562761\/\">Yuan M, Cazala A, Goedeke S, Leibold C, Sauer J-F, <strong>Bartos M<\/strong> (2025) Predictive goal coding by dentate gyrus somatostatin-expressing interneurons in male mice. Nature Communications 16(1):5382. doi: 10.1038\/s41467-025-60841-y.<\/a><\/li>\n<li class=\"docsum-content\"><a href=\"https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(25)00191-3\">Muysers H, <strong>Bartos M<\/strong>, Sauer J-F (2025) Conjoint generalized and trajectory-specific coding of task structure by prefrontal neurons. Cell Reports\u00a0 <span class=\"cit\">44(3):115420<\/span><\/a><\/li>\n<\/ul>\n<\/div>\n<p>2024<\/p>\n<ul>\n<li>\n<div class=\"docsum-wrap\">\n<div class=\"docsum-content\"><span class=\"docsum-authors full-authors\">Hong I, Kim J, Hainmueller T, Kim DW, Keijser J, Johnson RC, Park SH, Limjunyawong N, Yang Z, Cheon D, Hwang T, Agarwal A, <strong>Cholvin T<\/strong>, Krienen FM, McCarroll SA, Dong X, Leopold DA, Blackshaw S, Sprekeler H, Bergles DE, <strong>Bartos M<\/strong>, Brown SP, Huganir RL. (2024) <a class=\"docsum-title\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39358515\/\" data-ga-category=\"result_click\" data-ga-action=\"1\" data-ga-label=\"39358515\" data-full-article-url=\"from_term=hong+bartos&amp;from_sort=date&amp;from_pos=1\" data-article-id=\"39358515\"> Calcium-permeable AMPA receptors govern PV neuron feature selectivity. <\/a><\/span><span class=\"docsum-journal-citation full-journal-citation\"><strong>Nature<\/strong>. 2024 Oct 2. doi: 10.1038\/s41586-024-08027-2. Online ahead of print.<\/span> <span class=\"citation-part\">PMID: <span class=\"docsum-pmid\">39358515<\/span><\/span><\/div>\n<div><\/div>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2211124724010532?via%3Dihub\">Zheng ZS, Husz\u00e1r R, Hainmueller T, <strong>Bartos M<\/strong>, Williams A, Buzs\u00e1ki G. (2024) Perpetual step-like restructuring of hippocampal circuit dynamics. <strong>Cell Reports<\/strong> 43(9):114702<\/a><\/p>\n<\/div>\n<\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(24)00714-9\">Huang L-W, Torelli F, Chen H-L, Bartos M (2024) Context and space coding in mossy cell population activity. Cell Reports 43(7):114386. doi: 10.1016\/j.celrep.2024.114386. Online ahead of print.<\/a><\/li>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41467-024-46350-4\"><span class=\"fontstyle0\">Muysers H<\/span><span class=\"fontstyle0\">, Chen H-L<\/span><span class=\"fontstyle0\">, Hahn J<\/span><span class=\"fontstyle0\">, Folschweiller S<\/span><span class=\"fontstyle0\">, <\/span><span class=\"fontstyle0\">Sigurdsson T<\/span><span class=\"fontstyle0\">, <strong>Sauer JF<\/strong>, <\/span><strong><span class=\"fontstyle0\">Bartos <\/span> M<\/strong> (2024) A persistent prefrontal reference frame across time and task rules. <strong>Nature Communications<\/strong> DOI 10.1038\/s41467-024-46350-4<\/a><\/li>\n<li><a href=\"https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(24)00134-7\"><span class=\"fontstyle0\">Kaufhold D,<\/span> <span class=\"fontstyle0\">Maristany de las Casas D,<\/span> <span class=\"fontstyle0\">Ocana-Fernandez M A,<\/span> <span class=\"fontstyle0\">Cazala A,<\/span><span class=\"fontstyle0\"> Yuan M, <\/span><span class=\"fontstyle0\">Kulik A,<\/span> <span class=\"fontstyle0\"><strong>Cholvin T<\/strong>,<\/span> <span class=\"fontstyle0\">Steup S,<\/span> <span class=\"fontstyle0\"><strong>Sauer JF<\/strong>,<\/span> <span class=\"fontstyle0\">Eyre MD,<\/span> <span class=\"fontstyle0\"><strong>Elgueta C<\/strong>,<\/span> <span class=\"fontstyle0\">Struber M, <\/span><span class=\"fontstyle0\"><strong>Bartos M<\/strong> (2024) Spine plasticity of dentate gyrus parvalbumin-positive interneurons is regulated by experience. <strong>Cell Reports<\/strong>\u00a0<\/span> <span class=\"fontstyle0\">43<\/span><span class=\"fontstyle1\">: 113806<\/span> https:\/\/doi.org\/10.1016\/j.celrep.2024.113806<\/a><\/li>\n<li>\n<div class=\"share dropdown-block\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38267409\/\"><span class=\"docsum-authors full-authors\">Hainmueller T, Cazala A, Huang LW, <strong>Bartos M<\/strong> (2024) <\/span>Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice. <span class=\"docsum-journal-citation full-journal-citation\"><strong>Nature Communications<\/strong> 15(1):714. doi: 10.1038\/s41467-024-44882-3.<\/span> <span class=\"citation-part\">PMID: <span class=\"docsum-pmid\">38267409<\/span><\/span><\/a><\/div>\n<\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38206890\/\">Sylte OC, Muysers H, Chen HL, <strong>Bartos M<\/strong>, Sauer JF (2024) Neuronal tuning to threat exposure remains stable in the mouse prefrontal cortex over multiple days. <strong>PLOS Biology<\/strong><span class=\"cit\">22(1):e3002475.<\/span><span class=\"citation-doi\"> doi: 10.1371\/journal.pbio.3002475. <\/span> <span class=\"secondary-date\"> eCollection 2024 Jan. <\/span><\/a><\/li>\n<\/ul>\n<p>2023<\/p>\n<ul>\n<li><a href=\"https:\/\/www.cell.com\/neuron\/fulltext\/S0896-6273(23)00213-1\">Hanganu-Opatz IL, Klausberger T, Sigurdsson T, Nieder A, Jacob SN, <strong>Bartos M<\/strong>, Sauer JF, Durstewitz D, Leibold C, Diester I (2023) Resolving the prefrontal mechanisms of adaptive cognitive behaviors: A cross-species perspective. <strong>Neuron<\/strong> 111:1020-1036.<\/a><\/li>\n<\/ul>\n<p>2022<\/p>\n<ul>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41467-022-34039-5\">Cholvin T, Bartos M (2022) Hemisphere-specific spatial representation by hippocampal granule cells.\u00a0<strong>Nature Com.\u00a0<\/strong>DOI: 10.1038\/s41467-022-34039-5.<\/a><\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35079030\/\">Str\u00fcber M, Sauer JF, Bartos M (2022)\u00a0Parvalbumin expressing interneurons control spike-phase coupling of hippocampal cells to theta oscillations.\u00a0<strong>Sci Rep<\/strong>. 112:1362<\/a><\/li>\n<li><a href=\"https:\/\/www.pnas.org\/content\/119\/6\/e2117300119\">Sauer JF, Folschweiller S, Bartos M (2022) Topographically organized representation of space and context in the medial prefrontal cortex.\u00a0<strong>PNAS<\/strong>\u00a0119\u00a0(6)\u00a0e2117300119.<\/a><\/li>\n<\/ul>\n<p>2021<\/p>\n<ul>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34619088\/\">Cholvin T, Hainmueller T, Bartos M (2021)\u00a0The hippocampus converts dynamic entorhinal inputs into stable spatial maps,\u00a0<strong>Neuron<\/strong>\u00a0109:3135-3148.<\/a><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div class=\"w-tabs-section\" id=\"be7a\"><button aria-controls=\"content-be7a\" class=\"w-tabs-section-header\"><div class=\"w-tabs-section-title\">2016 &#8211; 2020<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-be7a\" aria-expanded=\"false\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><div id=\"content-lce2\" class=\"w-tabs-section-content\" aria-expanded=\"true\">\n<div class=\"w-tabs-section-content-h i-cf\">\n<div class=\"wpb_text_column\">\n<div class=\"wpb_wrapper\">\n<p>2020<\/p>\n<ul>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41583-019-0260-z\">Hainmueller T, Bartos M (2020) Dentate gyrus circuits for encoding, retrieval and discrimination of episodic memories. <strong>Nature Rev Neurosci<\/strong>, 21:153-68.<\/a><\/li>\n<li><a href=\"http:\/\/pubmed.ncbi.nlm.nih.gov\/33349333\/\">Paschen E, Elgueta C, Heining K, Vieira D, Kleis P, Orcinha C, H\u00e4ussler U, Bartos M, Egert U, Janz P, Haas C (2020) Hippocampal low-frequency stimulation prevents seizure generation in a mouse model of mesial temporal lobe epilepsy.<strong>\u00a0elife<\/strong>\u00a010.7554\/elife.54518.<\/a><\/li>\n<\/ul>\n<div id=\"content-h94e\" class=\"w-tabs-section-content\" aria-expanded=\"true\">\n<div class=\"w-tabs-section-content-h i-cf\">\n<div class=\"wpb_text_column\">\n<div class=\"wpb_wrapper\">\n<p>2019<\/p>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Dendritic+inhibition+differentially+regulates+excitability+of+dentate+gyrus+parvalbumin-expressing+interneurons+and+granule+cells.\">Elgueta C, Bartos M (2019) Dendritic inhibition differentially regulates excitability of dentate gyrus parvalbumin-expressing interneurons and granule cells.\u00a0<strong>Nature Comm<\/strong>\u00a010:5561. https:\/\/doi.org\/10.1038\/s41467-01913533-3.<\/a><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6716454\/\">Eyre MD, Bartos M (2019) Somatostatin-Expressing Interneurons Form Axonal Projections to the Contralateral Hippocampus.<strong>\u00a0Front Neural Circuits,\u00a0<\/strong>13:56. Published 2019 Aug 23. doi:10.3389\/fncir.2019.00056<\/a><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Holz+A%2C+M%C3%BClsch+F%2C+Schwarz+MK%2C+Hollmann+M%2C+D%C3%B6br%C3%B6ssy+MD%2C+Coenen+VA%2C+Bartos+M%2C+Normann+C%2C+Biber+K%2C+van+Calker+D%2C+Serchov+T.+Enhanced+mGlu5+Signaling+in+Excitatory+Neurons+Promotes+Rapid+Antidepressant+Effects+via+AMPA+Receptor+Activation.+Neuron.+2019\">Holz A, M\u00fclsch F, Schwarz MK, Hollmann M, D\u00f6br\u00f6ssy MD, Coenen VA, Bartos M, Normann C, Biber K, van Calker D, Serchov T (2019) Enhanced mGlu5 signaling in excitatory neurons promotes rapid antidepressant effects via AMPA receptor activation. <strong>Neuron<\/strong>. 2019 Jul 23. pii: S0896-6273(19)30637-3. doi: 10.1016\/j.neuron.2019.07.011.<\/a><\/li>\n<\/ul>\n<p>2018<\/p>\n<ul>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41586-018-0191-2\">Hainm\u00fcller T, Bartos M (2018) Parallel emergence of stable and dynamic memory engrams in the hippocampus.\u00a0<strong>Nature\u00a0<\/strong>558:292-96.<\/a><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Recording+Spatially+Restricted+Oscillations+in+the+Hippocampus+of+Behaving+Mice.\">Sauer JF, Str\u00fcber M, Bartos M (2018) Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice.\u00a0<strong>Jove-j Vis Exp\u00a0<\/strong>doi:10.3791\/57714.<\/a><\/li>\n<\/ul>\n<p>2017<\/p>\n<ul>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41467-017-00936-3\">Str\u00fcber M, Sauer JF, Jonas P, Bartos M (2017) Distance-dependent inhibition supports focality of gamma oscillations. (2017) <strong>Nature Commun<\/strong>. DOI: 10.1038\/s41467-017-00936-3.<\/a><\/li>\n<li><a href=\"https:\/\/elifesciences.org\/content\/6\/e21105?utm_source=content_alert&amp;utm_medium=email&amp;utm_content=fulltext&amp;utm_campaign=elife-alerts\">Yuan M, Meyer T, Benkowitz C, Savanthrapadian S, Ansel-Bollepalli L, Foggetti A, Wulff P, Alcami P, Elgueta C, Bartos M (2017) Somatostatin-positive interneurons in the dentate gyrus of mice provide local- and long-range septal synaptic inhibition.\u00a0<strong>eLife<\/strong>\u00a02017;6 e21105<\/a><\/li>\n<li><a href=\"http:\/\/rdcu.be\/qqtJ\">Biskamp J, Bartos M, Sauer JF (2017) Organization of prefrontal network activity by respiration-related oscillations.\u00a0<strong>Sci Rep<\/strong>\u00a07:45508<\/a><\/li>\n<\/ul>\n<p>2016<\/p>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27073230\">Janz P, Savathrapadian S, H\u00e4ussler U, Kilias A, Nestel A, Kretz O, Kirsch M, Bartos M, Egert U, Haas C (2016) Synaptic remodeling of entorhinal input contributes to an aberrant hippocampal network in temporal lobe epilepsy. <strong>Cereb Cortex<\/strong>\u00a0doi: 10.1093\/cercor\/bhw093<\/a><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div class=\"w-tabs-section\" id=\"b1e4\"><button aria-controls=\"content-b1e4\" class=\"w-tabs-section-header\"><div class=\"w-tabs-section-title\">2011 &#8211; 2015<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-b1e4\" aria-expanded=\"false\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><div id=\"content-a63d\" class=\"w-tabs-section-content\" aria-expanded=\"true\">\n<div class=\"w-tabs-section-content-h i-cf\">\n<div class=\"wpb_text_column\">\n<div class=\"wpb_wrapper\">\n<p>2015<\/p>\n<ul>\n<li><a href=\"http:\/\/www.jneurosci.org\/content\/35\/10\/4131.short\">Elgueta C, K\u00f6hler J, Bartos M (2015)\u00a0 Persistent discharges in dentate gyrus perisoma-inhibiting interneurons require hyperpolarization-activated cyclic nucleotide-gated channel activation.\u00a0<strong>J Neurosci<\/strong>\u00a035:4131-4139<\/a><\/li>\n<li><a href=\"http:\/\/elifesciences.org\/content\/early\/2015\/03\/03\/eLife.04979\">Sauer JF, Str\u00fcber M, Bartos M (2015) Impaired fast-spiking interneuron function in a genetic mouse model of depression.\u00a0<strong>eLife<\/strong>\u00a02015;10.7554\/eLife.04979<\/a><\/li>\n<li><a href=\"http:\/\/www.pnas.org\/content\/early\/2015\/01\/08\/1412996112.full.pdf+html\">Str\u00fcber M, Jonas P, Bartos M (2015) Strength and duration of perisomatic GABAergic inhibition depend on distance between synaptically connected cells.\u00a0<strong>PNAS USA<\/strong>\u00a0ePub ahead of print;\u00a0doi:10.1073\/pnas.1423628112<\/a><\/li>\n<\/ul>\n<p>2014<\/p>\n<ul>\n<li><a href=\"http:\/\/www.pnas.org\/content\/111\/36\/13211.long\">Hainm\u00fcller T, Krieglstein K, Kulik A, Bartos M (2014) Joint CP-AMPA and group I mGlu receptor activation is required for synaptic plasticity in dentate gyrus fast-spiking interneurons.\u00a0<strong>PNAS<\/strong>\u00a0<strong>USA<\/strong>\u00a0111:13211-13216.<\/a><\/li>\n<li><a href=\"http:\/\/www.jneurosci.org\/content\/34\/24\/8197.long\">Savanthrapadian S, Meyer T, Elgueta C, Booker S, Vida I, Bartos M (2014) Synaptic properties of SOM- and CCK-expressing cells in dentate gyrus interneuron networks.\u00a0<strong>J Neurosci<\/strong>\u00a034:8197-8209.<\/a><\/li>\n<\/ul>\n<p>2013<\/p>\n<ul>\n<li><a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hipo.22214\/abstract;jsessionid=2800D77DD040CD239AF90A1F8C30588E.f03t04\">Hosp JA, Str\u00fcber M, Yanagawa Y, Obata K, Vida I, Jonas P, Bartos M (2013) Morpho-physiological criteria divide dentate gyrus interneurons into classes. <strong>Hippocampus<\/strong>\u00a024:189-203.<\/a><\/li>\n<\/ul>\n<p>2012<\/p>\n<ul>\n<li><a href=\"http:\/\/jp.physoc.org\/content\/590\/4\/669.abstract\">Bartos M, Elgueta C. (2012) Functional characteristics of parvalbumin- and cholecystokinin-expressing basket cells.\u00a0<strong>J Physiol (Lond)<\/strong>\u00a0590:669-681.<\/a><\/li>\n<li><a href=\"http:\/\/www.jneurosci.org\/content\/32\/12\/4224.long\">Sauer J-F, Str\u00fcber M, Bartos M (2012) Interneurons provide circuit-specific depolarization and hyperpolarization. <strong>J Neurosci<\/strong>\u00a032:4224-4229.<\/a><\/li>\n<\/ul>\n<p>2011<\/p>\n<ul>\n<li><a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0028390810003527\" target=\"_blank\" rel=\"noopener\">Bartos M, Alle H, Vida I (2011) Role of microcircuit structure and input integration in hippocampal interneuron recruitment and plasticity. <strong>Neuropharmacol<\/strong>\u00a060:730-739.<\/a><\/li>\n<li><a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1460-9568.2011.07872.x\/abstract\">Sauer J-F, Bartos M (2011) Postnatal differentiation of cortical interneuron signalling.\u00a0<strong>Eur J Neurosci\u00a0<\/strong>34:1687-1696.<\/a><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div class=\"w-tabs-section\" id=\"x562\"><button aria-controls=\"content-x562\" class=\"w-tabs-section-header\"><div class=\"w-tabs-section-title\">2006 &#8211; 2010<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-x562\" aria-expanded=\"false\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><div id=\"content-w857\" class=\"w-tabs-section-content\" aria-expanded=\"true\">\n<div class=\"w-tabs-section-content-h i-cf\">\n<div class=\"wpb_text_column\">\n<div class=\"wpb_wrapper\">\n<section class=\"l-section wpb_row us_custom_8535c5f4 height_small\">\n<div class=\"l-section-h i-cf\">\n<div class=\"g-cols vc_row via_flex valign_top type_default stacking_default\">\n<div class=\"vc_col-sm-12 wpb_column vc_column_container\">\n<div class=\"vc_column-inner\">\n<div class=\"wpb_wrapper\">\n<div class=\"wpb_text_column\">\n<div class=\"wpb_wrapper\">\n<div id=\"content-a2b8\" class=\"w-tabs-section-content\" aria-expanded=\"true\">\n<div class=\"w-tabs-section-content-h i-cf\">\n<div class=\"wpb_text_column\">\n<div class=\"wpb_wrapper\">\n<div id=\"content-h94e\" class=\"w-tabs-section-content\" aria-expanded=\"true\">\n<div class=\"w-tabs-section-content-h i-cf\">\n<div class=\"wpb_text_column\">\n<div class=\"wpb_wrapper\">\n<p>2010<\/p>\n<ul>\n<li><a href=\"http:\/\/www.jneurosci.org\/content\/30\/35\/11826.long\">Sambandan S, Sauer JF, Vida I, Bartos M (2010) Associative plasticity at excitatory synapses facilitates recruitment of fast-spiking interneurons in the dentate gyrus.\u00a0<strong>J Neurosci<\/strong>\u00a030:11826-11837.<\/a><\/li>\n<\/ul>\n<p>2009<\/p>\n<ul>\n<li><a href=\"http:\/\/www.pnas.org\/content\/106\/9\/3561.long\">Wulff P, Ponomarenko AA, Bartos M, Krotkova TM, Fuchs EC, Tort MA, Kopell N, Wisden W, Monyer H (2009) Hippocampal theta rhythm and its coupling with gamma oscillations require fast inhibition onto parvalbumin positive interneurons. <strong>PNAS<\/strong>\u00a0<strong>USA<\/strong>\u00a0106:3561-3566.<\/a><\/li>\n<\/ul>\n<p>2008<\/p>\n<ul>\n<li><a href=\"http:\/\/www.jneurosci.org\/content\/28\/48\/12956.long\">Doischer, D, Hosp, P, Yanagawa, Y, Obata, K, Jonas, P, Vida, I, Bartos, M (2008) Postnatal development of hippocampal basket cells from slow to fast signaling devices. <strong>J Neurosci<\/strong>\u00a026:12956-12968.<\/a><\/li>\n<\/ul>\n<div id=\"content-sffc\" class=\"w-tabs-section-content\" aria-expanded=\"true\">\n<div class=\"w-tabs-section-content-h i-cf\">\n<div class=\"wpb_text_column\">\n<div class=\"wpb_wrapper\">\n<p>2007<\/p>\n<ul>\n<li><a href=\"http:\/\/www.nature.com\/nrn\/journal\/v8\/n1\/full\/nrn2044.html\">Bartos M, Vida I, Jonas P (2007) Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks.\u00a0<strong>Nat Rev Neurosci\u00a0<\/strong>8:45-56.<\/a><\/li>\n<\/ul>\n<p>2006<\/p>\n<ul>\n<li><a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0896627305010627\">Vida I, Bartos M, Jonas P (2006) Shunting inhibition improves robustness of gamma oscillations in hippocampal interneuron networks by homogenizing firing rates.\u00a0<strong>Neuron<\/strong>\u00a049:107-117 (equal contribution of the authors).<\/a><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row height_custom\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><h2>Finanzierung<\/h2>\n<\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"w-image footerlogo align_left\"><a target=\"_blank\" href=\"https:\/\/www.dfg.de\/\" rel=\"noopener\" aria-label=\"Link\" class=\"w-image-h\"><img loading=\"lazy\" decoding=\"async\" width=\"744\" height=\"150\" src=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/01\/dfg-logo.png\" class=\"attachment-full size-full\" alt=\"\" srcset=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/01\/dfg-logo.png 744w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/01\/dfg-logo-600x121.png 600w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/01\/dfg-logo-300x60.png 300w\" sizes=\"auto, (max-width: 744px) 100vw, 744px\" \/><\/a><\/div><div class=\"w-image footerlogo align_left\"><a target=\"_blank\" 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href=\"https:\/\/www.brainlinks-braintools.uni-freiburg.de\/\" rel=\"noopener\" aria-label=\"Link\" class=\"w-image-h\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"200\" src=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/01\/footer-logo-brain-links.png\" class=\"attachment-full size-full\" alt=\"\" \/><\/a><\/div><\/div><\/div><\/div><\/div><\/div><\/section>\n<\/section>","protected":false},"excerpt":{"rendered":"Labor f\u00fcr System- und Zellul\u00e4re Neurowissenschaften Prof. Marlene Bartos &#8211; Forschungsgruppe Systemische und zellul\u00e4re Neurowissenschaften Wir wollen verstehen, wie die dendritische Integration der Aktivit\u00e4t in den Hauptzellen und GABAergen Interneuronen die Funktion der Mikroschaltkreise und das Verhalten beeinflusst. Curriculum Vitae Forschung Ein grundlegendes und faszinierendes Merkmal des S\u00e4ugetiergehirns ist seine F\u00e4higkeit, neue Informationen aufzunehmen und...","protected":false},"author":4,"featured_media":3143,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1498","page","type-page","status-publish","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Prof. Dr. Marlene Bartos - Labor f\u00fcr System- und Zellul\u00e4re Neurowissenschaften - Institute of Physiology, Department 1 | University of Freiburg<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/physiology-freiburg.de\/de\/prof-dr-marlene-bartos-laboratory-of-systems-cellular-neuroscience\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Prof. Dr. Marlene Bartos - Labor f\u00fcr System- und Zellul\u00e4re Neurowissenschaften - Institute of Physiology, Department 1 | University of Freiburg\" \/>\n<meta property=\"og:url\" content=\"https:\/\/physiology-freiburg.de\/de\/prof-dr-marlene-bartos-laboratory-of-systems-cellular-neuroscience\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute of Physiology, Department 1 | University of Freiburg\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-27T16:05:53+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2024\/05\/Picture1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1023\" \/>\n\t<meta property=\"og:image:height\" content=\"830\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"13\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/physiology-freiburg.de\\\/de\\\/prof-dr-marlene-bartos-laboratory-of-systems-cellular-neuroscience\\\/\",\"url\":\"https:\\\/\\\/physiology-freiburg.de\\\/de\\\/prof-dr-marlene-bartos-laboratory-of-systems-cellular-neuroscience\\\/\",\"name\":\"Prof. Dr. Marlene Bartos - Labor f\u00fcr System- und Zellul\u00e4re Neurowissenschaften - Institute of Physiology, Department 1 | University of Freiburg\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/physiology-freiburg.de\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/physiology-freiburg.de\\\/de\\\/prof-dr-marlene-bartos-laboratory-of-systems-cellular-neuroscience\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/physiology-freiburg.de\\\/de\\\/prof-dr-marlene-bartos-laboratory-of-systems-cellular-neuroscience\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/physiology-freiburg.de\\\/wp-content\\\/uploads\\\/2024\\\/05\\\/Picture1.jpg\",\"datePublished\":\"2023-02-14T15:45:57+00:00\",\"dateModified\":\"2025-06-27T16:05:53+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/physiology-freiburg.de\\\/de\\\/prof-dr-marlene-bartos-laboratory-of-systems-cellular-neuroscience\\\/#breadcrumb\"},\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/physiology-freiburg.de\\\/de\\\/prof-dr-marlene-bartos-laboratory-of-systems-cellular-neuroscience\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\\\/\\\/physiology-freiburg.de\\\/de\\\/prof-dr-marlene-bartos-laboratory-of-systems-cellular-neuroscience\\\/#primaryimage\",\"url\":\"https:\\\/\\\/physiology-freiburg.de\\\/wp-content\\\/uploads\\\/2024\\\/05\\\/Picture1.jpg\",\"contentUrl\":\"https:\\\/\\\/physiology-freiburg.de\\\/wp-content\\\/uploads\\\/2024\\\/05\\\/Picture1.jpg\",\"width\":1023,\"height\":830},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/physiology-freiburg.de\\\/de\\\/prof-dr-marlene-bartos-laboratory-of-systems-cellular-neuroscience\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/physiology-freiburg.de\\\/de\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Prof. Dr. Marlene Bartos &#8211; 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