{"id":2940,"date":"2024-03-13T20:05:43","date_gmt":"2024-03-13T19:05:43","guid":{"rendered":"https:\/\/physiology-freiburg.de\/?page_id=2940"},"modified":"2024-03-13T20:40:07","modified_gmt":"2024-03-13T19:40:07","slug":"dr-thibault-cholvin-forschungsgruppe-hippocampus-interaktionen","status":"publish","type":"page","link":"https:\/\/physiology-freiburg.de\/de\/forschung\/dr-thibault-cholvin-forschungsgruppe-hippocampus-interaktionen\/","title":{"rendered":"Dr. Thibault Cholvin &#8211; Forschungsgruppe Hippocampus-Interaktionen"},"content":{"rendered":"<section class=\"wpb-content-wrapper\"><section class=\"l-section wpb_row height_custom\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"w-separator size_large\"><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><h1 style=\"text-align: center;\">Forschungsgruppe Hippocampus-Interaktionen<\/h1>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row height_custom\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-3\/5 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><h6><strong>gef\u00fchrt von<\/strong><\/h6>\n<h2>Dr. Thibault Cholvin<\/h2>\n<p>Mithilfe der In-vivo-Zweiphotonen-Kalziumbildgebung bei verhaltensgest\u00f6rten M\u00e4usen untersuchen wir, wie das Gehirn Erfahrungen in kortiko-hippocampalen Netzwerken erfasst und langfristig speichert.<\/p>\n<p>Kontact: <a href=\"mailto:thibault.cholvin@physiologie.uni-freiburg.de\">thibault-cholvin@physiologie.uni-freiburg.de<\/a><\/p>\n<\/div><\/div><\/div><\/div><\/div><div class=\"vc_col-sm-2\/5 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"w-image align_none\"><div class=\"w-image-h\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/TC_photo_website_07s-1024x683.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/TC_photo_website_07s-1024x683.png 1024w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/TC_photo_website_07s-600x400.png 600w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/TC_photo_website_07s-300x200.png 300w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/TC_photo_website_07s-200x133.png 200w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/TC_photo_website_07s.png 1680w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row height_custom\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><h2>Forschung<\/h2>\n<p>Wir erforschen die r\u00e4umliche Navigation und das episodische Ged\u00e4chtnis bei verhaltensgest\u00f6rten M\u00e4usen. Mithilfe der Zwei-Photonen-Kalzium-Bildgebung in vivo verfolgen wir die Aktivit\u00e4t von Neuronen \u00fcber l\u00e4ngere Zeitr\u00e4ume (mehrere Tage\/Wochen) und beleuchten so die Eigenschaften der verschiedenen Unterregionen des Hippocampus (CA1, CA3, DG) sowie deren kortikale Eing\u00e4nge (wie die axonalen Projektionen aus dem entorhinalen Kortex). Dazu kombinieren wir Zwei-Photonen-Bildgebung und virtuelle Realit\u00e4t, um die Aktivit\u00e4t von Hunderten von Neuronen oder Axonen gleichzeitig zu erfassen, w\u00e4hrend die Maus durch virtuelle Umgebungen navigiert. Schlie\u00dflich nutzen wir die aufgezeichnete Zell- oder Axonaktivit\u00e4t, um den gleichzeitigen Standort und die Umgebung der Tiere zu entschl\u00fcsseln und so auf die relative Beteiligung dieser Hirnregionen am r\u00e4umlichen Ged\u00e4chtnis zu schlie\u00dfen.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row height_custom\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><h2>Teckniken<\/h2>\n<\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><h3>In-vivo-Zweiphotonen-Kalzium-Bildgebung<\/h3>\n<\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"w-tabs layout_hor style_default switch_click has_scrolling\" style=\"--sections-title-size:1em\"><div class=\"w-tabs-list items_6 align_none\"><div class=\"w-tabs-list-h\"><button class=\"w-tabs-item active\" aria-controls=\"content-z85e\"><span class=\"w-tabs-item-title\">Virtual Reality-Einrichtung f\u00fcr M\u00e4use<\/span><\/button><button class=\"w-tabs-item\" aria-controls=\"content-t7b1\"><span class=\"w-tabs-item-title\">Neuronen<\/span><\/button><button class=\"w-tabs-item\" aria-controls=\"content-f1c3\"><span class=\"w-tabs-item-title\">Axonale Projektionen<\/span><\/button><button class=\"w-tabs-item\" aria-controls=\"content-i7fa\"><span class=\"w-tabs-item-title\">Konnektivit\u00e4t der neuronalen Schaltkreise<\/span><\/button><button class=\"w-tabs-item\" aria-controls=\"content-a31a\"><span class=\"w-tabs-item-title\">Chemogenetik<\/span><\/button><button class=\"w-tabs-item\" aria-controls=\"content-mb38\"><span class=\"w-tabs-item-title\">Dekodierung neuronaler Aktivit\u00e4t<\/span><\/button><\/div><\/div><div class=\"w-tabs-sections titles-align_none icon_chevron cpos_right\"><div class=\"w-tabs-section active\" id=\"z85e\"><button aria-controls=\"content-z85e\" class=\"w-tabs-section-header active\"><div class=\"w-tabs-section-title\">Virtual Reality-Einrichtung f\u00fcr M\u00e4use<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-z85e\" aria-expanded=\"true\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"g-cols wpb_row via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-4 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Wir f\u00fchren Zwei-Photonen-Kalzium-Bildgebung bei M\u00e4usen durch, die den Kopf fixieren und zielgerichtete Aufgaben in vertrauter oder virtueller Umgebung ausf\u00fchren.<\/p>\n<\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"w-image align_none\"><div class=\"w-image-h\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"670\" src=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Treadmill_VR_01-1024x670.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Treadmill_VR_01-1024x670.png 1024w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Treadmill_VR_01-600x393.png 600w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Treadmill_VR_01-300x196.png 300w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Treadmill_VR_01-200x131.png 200w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Treadmill_VR_01.png 1823w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/div><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Das Tier steht auf einer luftgetragenen Styroporkugel, die es ihm erm\u00f6glicht, durch virtuelle Welten zu navigieren, w\u00e4hrend seine tats\u00e4chliche Position konstant bleibt.<\/p>\n<\/div><\/div><div class=\"w-separator size_small\"><\/div><\/div><\/div><\/div><div class=\"vc_col-sm-4 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Die Bildschirme sind in einem sechseckigen Bogen um die Maus herum angeordnet und befinden sich in einem Abstand von ca. 25 cm vom Kopf des Tieres. Sie decken ~260\u00b0 des horizontalen und ~60\u00b0 des vertikalen Gesichtsfeldes der Maus ab.<\/p>\n<\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"w-image align_none\"><div class=\"w-image-h\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"857\" src=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Contexts_maps-1024x857.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Contexts_maps-1024x857.png 1024w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Contexts_maps-600x502.png 600w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Contexts_maps-300x251.png 300w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Contexts_maps-200x167.png 200w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Contexts_maps.png 1059w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/div><\/div><div class=\"w-separator size_small\"><\/div><\/div><\/div><\/div><div class=\"vc_col-sm-4 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\">\r\n    <div style=\"max-width:380px;\">        \r\n    <video id=\"plyr69d92428f244b\" autoplay loop muted controls class=\"easy-video-player\">\r\n       <source src=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/BehavCtxA.mp4\" type=\"video\/mp4\" \/>\r\n    <\/video>\r\n    <\/div>    <script>\r\n        const evplayerplyr69d92428f244b = new Plyr(document.getElementById('plyr69d92428f244b'));\r\n        evplayerplyr69d92428f244b.ratio = '16:9';\r\n        evplayerplyr69d92428f244b.iconUrl = 'https:\/\/physiology-freiburg.de\/wp-content\/plugins\/easy-video-player\/lib\/plyr.svg';\r\n        evplayerplyr69d92428f244b.blankVideo = 'https:\/\/physiology-freiburg.de\/wp-content\/plugins\/easy-video-player\/lib\/blank.mp4';  \r\n    <\/script>\n<\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\">\r\n    <div style=\"max-width:380px;\">        \r\n    <video id=\"plyr69d92428f271c\" autoplay loop muted controls class=\"easy-video-player\">\r\n       <source src=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/BehavCtxB.mp4\" type=\"video\/mp4\" \/>\r\n    <\/video>\r\n    <\/div>    <script>\r\n        const evplayerplyr69d92428f271c = new Plyr(document.getElementById('plyr69d92428f271c'));\r\n        evplayerplyr69d92428f271c.ratio = '16:9';\r\n        evplayerplyr69d92428f271c.iconUrl = 'https:\/\/physiology-freiburg.de\/wp-content\/plugins\/easy-video-player\/lib\/plyr.svg';\r\n        evplayerplyr69d92428f271c.blankVideo = 'https:\/\/physiology-freiburg.de\/wp-content\/plugins\/easy-video-player\/lib\/blank.mp4';  \r\n    <\/script>\n<\/div><\/div><div class=\"w-separator size_small\"><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"w-tabs-section\" id=\"t7b1\"><button aria-controls=\"content-t7b1\" class=\"w-tabs-section-header\"><div class=\"w-tabs-section-title\">Neuronen<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-t7b1\" aria-expanded=\"false\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"g-cols wpb_row via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-6 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Wir verwenden in vivo Zwei-Photonen-Kalzium-Bildgebung, um die Aktivit\u00e4t von Hunderten von Zellen in der einen oder anderen Subregion des Hippocampus gleichzeitig zu erfassen. In diesem Beispiel haben wir GCaMP im Hippocampus panneuronal exprimiert, so dass wir die Pyramidenzellen in CA1 und CA3 sowie die K\u00f6rnerzellen des Gyrus dentatus abbilden konnten.<\/p>\n<\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"w-image align_none\"><div class=\"w-image-h\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"421\" src=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/dHip_GCaMP-1-1024x421.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/dHip_GCaMP-1-1024x421.png 1024w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/dHip_GCaMP-1-600x247.png 600w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/dHip_GCaMP-1-300x123.png 300w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/dHip_GCaMP-1-200x82.png 200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Die nachstehenden Kurven zeigen die Aktivit\u00e4t einer einzelnen K\u00f6rnerzelle \u00fcber 15 Durchl\u00e4ufe in zwei verschiedenen Umgebungen; beachten Sie das zuverl\u00e4ssige Vorhandensein eines Ortsfeldes in Kontext A, im Gegensatz zum auff\u00e4lligen Fehlen der Aktivit\u00e4t dieser Zelle in Kontext B.<\/p>\n<\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"w-image align_none\"><div class=\"w-image-h\"><img loading=\"lazy\" decoding=\"async\" width=\"908\" height=\"367\" src=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/MEC_DREADDs_hM4Di_SingleCellTraces.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/MEC_DREADDs_hM4Di_SingleCellTraces.png 908w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/MEC_DREADDs_hM4Di_SingleCellTraces-600x243.png 600w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/MEC_DREADDs_hM4Di_SingleCellTraces-300x121.png 300w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/MEC_DREADDs_hM4Di_SingleCellTraces-200x81.png 200w\" sizes=\"auto, (max-width: 908px) 100vw, 908px\" \/><\/div><\/div><div class=\"w-separator size_small\"><\/div><\/div><\/div><\/div><div class=\"vc_col-sm-6 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Dieses Video zeigt ein typisches Beispiel f\u00fcr ein Sichtfeld, das eine gro\u00dfe Population von K\u00f6rnerzellen umfasst, die wir in unseren Experimenten abbilden k\u00f6nnen.<\/p>\n<\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\">\r\n    <div style=\"max-width:610px;\">        \r\n    <video id=\"plyr69d9242901678\" autoplay loop muted controls class=\"easy-video-player\">\r\n       <source src=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/DG_PC_Video_35sec.mp4\" type=\"video\/mp4\" \/>\r\n    <\/video>\r\n    <\/div>    <script>\r\n        const evplayerplyr69d9242901678 = new Plyr(document.getElementById('plyr69d9242901678'));\r\n        evplayerplyr69d9242901678.ratio = '16:9';\r\n        evplayerplyr69d9242901678.iconUrl = 'https:\/\/physiology-freiburg.de\/wp-content\/plugins\/easy-video-player\/lib\/plyr.svg';\r\n        evplayerplyr69d9242901678.blankVideo = 'https:\/\/physiology-freiburg.de\/wp-content\/plugins\/easy-video-player\/lib\/blank.mp4';  \r\n    <\/script>\n<\/div><\/div><div class=\"w-separator size_small\"><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"w-tabs-section\" id=\"f1c3\"><button aria-controls=\"content-f1c3\" class=\"w-tabs-section-header\"><div class=\"w-tabs-section-title\">Axonale Projektionen<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-f1c3\" aria-expanded=\"false\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"g-cols wpb_row via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-6 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Die In-vivo-Zweiphotonen-Kalziumbildgebung kann auch auf axonale Projektionen angewandt werden, so dass wir die Aktivit\u00e4t von Hunderten von Axonendigungen erfassen k\u00f6nnen, die von Neuronen in entfernten Hirnregionen (wie dem entorhinalen Kortex) stammen und in den Hippocampus projizieren.<\/p>\n<\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"w-image align_none\"><div class=\"w-image-h\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"546\" src=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Group_image-1024x546.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Group_image-1024x546.png 1024w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Group_image-600x320.png 600w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Group_image-300x160.png 300w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Group_image-200x107.png 200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Die folgenden Spuren zeigen die Aktivit\u00e4t eines einzelnen Boutons (Axonterminal) \u00fcber 15 Durchl\u00e4ufe in zwei verschiedenen Umgebungen; beachten Sie das Vorhandensein von Ortsfeldern in beiden Kontexten, jedoch an unterschiedlichen Stellen je nach Kontext (remapping).<\/p>\n<\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"w-image align_none\"><div class=\"w-image-h\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"512\" src=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/ExampleMECbouton-1024x512.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/ExampleMECbouton-1024x512.png 1024w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/ExampleMECbouton-600x300.png 600w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/ExampleMECbouton-300x150.png 300w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/ExampleMECbouton-200x100.png 200w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/ExampleMECbouton.png 1563w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/div><\/div><div class=\"w-separator size_small\"><\/div><\/div><\/div><\/div><div class=\"vc_col-sm-6 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Dieses Video zeigt ein typisches Beispiel f\u00fcr das Sichtfeld, das zahlreiche axonale Projektionen vom MEC zum Gyrus dentatus (mittlere Molekularschicht) umfasst, wie wir sie in unseren Experimenten abbilden k\u00f6nnen.<\/p>\n<\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\">\r\n    <div style=\"max-width:610px;\">        \r\n    <video id=\"plyr69d9242904089\" autoplay loop muted controls class=\"easy-video-player\">\r\n       <source src=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/DG_BT_Video_35sec-1.mp4\" type=\"video\/mp4\" \/>\r\n    <\/video>\r\n    <\/div>    <script>\r\n        const evplayerplyr69d9242904089 = new Plyr(document.getElementById('plyr69d9242904089'));\r\n        evplayerplyr69d9242904089.ratio = '16:9';\r\n        evplayerplyr69d9242904089.iconUrl = 'https:\/\/physiology-freiburg.de\/wp-content\/plugins\/easy-video-player\/lib\/plyr.svg';\r\n        evplayerplyr69d9242904089.blankVideo = 'https:\/\/physiology-freiburg.de\/wp-content\/plugins\/easy-video-player\/lib\/blank.mp4';  \r\n    <\/script>\n<\/div><\/div><div class=\"w-separator size_small\"><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"w-tabs-section\" id=\"i7fa\"><button aria-controls=\"content-i7fa\" class=\"w-tabs-section-header\"><div class=\"w-tabs-section-title\">Konnektivit\u00e4t der neuronalen Schaltkreise<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-i7fa\" aria-expanded=\"false\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"g-cols wpb_row via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-4 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Mit retrograden Tracern wie Choleratoxin Untereinheit B (CTB), die mit verschiedenen Fluorophoren (z. B. Alexa Fluor 488 (gr\u00fcn), 555 (rot) oder 647 (blau)) konjugiert sind, k\u00f6nnen wir mehrere neuronale Bahnen innerhalb desselben Gehirns untersuchen, z. B. die Projektionen vom entorhinalen Kortex zu bestimmten Unterregionen des Hippocampus. In dem hier vorgestellten Beispiel wurden drei verschiedene CTB-Varianten in CA1, CA3 bzw. DG bei einem einzigen Tier injiziert, um die Unterschiede (z. B. die Schichtspezifit\u00e4t) in der Konnektivit\u00e4t zwischen dem entorhinalen Kortex und den einzelnen Unterregionen des Hippocampus aufzuzeigen.<\/p>\n<\/div><\/div><\/div><\/div><\/div><div class=\"vc_col-sm-8 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"w-image align_none\"><div class=\"w-image-h\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"548\" src=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/RetroCTB_small-1024x548.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/RetroCTB_small-1024x548.png 1024w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/RetroCTB_small-600x321.png 600w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/RetroCTB_small-300x161.png 300w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/RetroCTB_small-200x107.png 200w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/RetroCTB_small.png 2000w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"w-tabs-section\" id=\"a31a\"><button aria-controls=\"content-a31a\" class=\"w-tabs-section-header\"><div class=\"w-tabs-section-title\">Chemogenetik<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-a31a\" aria-expanded=\"false\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"g-cols wpb_row via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-6 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Chemogenetische Hilfsmittel wie Designer-Rezeptoren, die ausschlie\u00dflich durch Designer-Drogen aktiviert werden (auch bekannt als DREADDs), erm\u00f6glichen die Fernsteuerung neuronaler Aktivit\u00e4ten. DREADDs sind k\u00fcnstlich hergestellte Muscarin- oder Opioidrezeptoren, die so lange stumm bleiben, bis sie durch spezifische Liganden (die durch eine einfache intraven\u00f6se Injektion verabreicht werden k\u00f6nnen) aktiviert werden. Je nach Typ k\u00f6nnen DREADD-Rezeptoren entweder eine Zunahme (hM3Dq) oder eine Abnahme (hM4Di) der neuronalen Aktivit\u00e4t bewirken.<\/p>\n<\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"w-image align_none\"><div class=\"w-image-h\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"640\" src=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/MEC_DREADDs_hM4Di-1024x640.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/MEC_DREADDs_hM4Di-1024x640.png 1024w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/MEC_DREADDs_hM4Di-600x375.png 600w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/MEC_DREADDs_hM4Di-300x188.png 300w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/MEC_DREADDs_hM4Di-200x125.png 200w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/MEC_DREADDs_hM4Di.png 1164w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>In diesem Beispiel kann die Aktivit\u00e4t der Sternzellen des MEC durch die Expression von hM4Di-Rezeptoren herunterreguliert werden, was uns die M\u00f6glichkeit gibt, die Bedeutung der von dieser Zellpopulation in den Hippocampus gelangenden Inputs f\u00fcr die Aktivit\u00e4t der Neuronen des Hippocampus zu bewerten.<\/p>\n<\/div><\/div><div class=\"w-separator size_small\"><\/div><\/div><\/div><\/div><div class=\"vc_col-sm-6 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Die folgenden Kurven zeigen die Aktivit\u00e4t einer einzelnen K\u00f6rnerzelle des Gyrus dentatus, die unter den Bedingungen der Grundlinie, PBS und Clozapin aufgezeichnet wurde. Nach Aktivierung der hMD4i-Rezeptoren, die von den stellaten Zellen der Schicht-2 des MEC exprimiert werden, durch Clozapin wird diese K\u00f6rnerzelle zum Schweigen gebracht.<\/p>\n<\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"w-image align_none\"><div class=\"w-image-h\"><img loading=\"lazy\" decoding=\"async\" width=\"908\" height=\"367\" src=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/MEC_DREADDs_hM4Di_SingleCellTraces.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/MEC_DREADDs_hM4Di_SingleCellTraces.png 908w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/MEC_DREADDs_hM4Di_SingleCellTraces-600x243.png 600w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/MEC_DREADDs_hM4Di_SingleCellTraces-300x121.png 300w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/MEC_DREADDs_hM4Di_SingleCellTraces-200x81.png 200w\" sizes=\"auto, (max-width: 908px) 100vw, 908px\" \/><\/div><\/div><div class=\"w-separator size_small\"><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"w-tabs-section\" id=\"mb38\"><button aria-controls=\"content-mb38\" class=\"w-tabs-section-header\"><div class=\"w-tabs-section-title\">Dekodierung neuronaler Aktivit\u00e4t<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-mb38\" aria-expanded=\"false\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"g-cols wpb_row via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><div class=\"g-cols wpb_row via_flex valign_top type_default stacking_default\">\n<div class=\"vc_col-sm-12 wpb_column vc_column_container\">\n<div class=\"vc_column-inner\">\n<div class=\"wpb_wrapper\">Um direkt zu untersuchen, wie verschiedene Neuronenpopulationen an der Kodierung von Raum und Kontext beteiligt sind, verwenden wir einen inversen Ansatz, bei dem wir von der aufgezeichneten Zell- (oder Bouton-) Aktivit\u00e4t ausgehen, um den gleichzeitigen Ort und Kontext der Tiere zu dekodieren (unter Verwendung einer auf Populationsvektoren basierenden Methode).<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div><div class=\"w-separator size_small\"><\/div><\/div><\/div><\/div><\/div><div class=\"g-cols wpb_row via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-6 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"w-image align_none\"><div class=\"w-image-h\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"437\" src=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Decoding_201-1024x437.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Decoding_201-1024x437.png 1024w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Decoding_201-600x256.png 600w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Decoding_201-300x128.png 300w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Decoding_201-200x85.png 200w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Decoding_201.png 1695w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/div><\/div><\/div><\/div><\/div><div class=\"vc_col-sm-6 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"w-image align_none\"><div class=\"w-image-h\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"437\" src=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Decoding_202-1024x437.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Decoding_202-1024x437.png 1024w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Decoding_202-600x256.png 600w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Decoding_202-300x128.png 300w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Decoding_202-200x85.png 200w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Decoding_202.png 1695w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"g-cols wpb_row via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-3 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>In dem hier vorgestellten Beispiel wurden aus allen aufgezeichneten Zellen einer bestimmten Sitzung zuf\u00e4llig Unterproben von 50 Zellen ausgew\u00e4hlt, entweder aus dem linken oder dem rechten Hippocampus.<\/p>\n<\/div><\/div><\/div><\/div><\/div><div class=\"vc_col-sm-3 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"w-image align_none\"><div class=\"w-image-h\"><img loading=\"lazy\" decoding=\"async\" width=\"756\" height=\"881\" src=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Decoding_204_Spa.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Decoding_204_Spa.png 756w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Decoding_204_Spa-515x600.png 515w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Decoding_204_Spa-257x300.png 257w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Decoding_204_Spa-200x233.png 200w\" sizes=\"auto, (max-width: 756px) 100vw, 756px\" \/><\/div><\/div><\/div><\/div><\/div><div class=\"vc_col-sm-3 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"w-image align_none\"><div class=\"w-image-h\"><img loading=\"lazy\" decoding=\"async\" width=\"740\" height=\"874\" src=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Decoding_203_Ctx.png\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Decoding_203_Ctx.png 740w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Decoding_203_Ctx-508x600.png 508w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Decoding_203_Ctx-254x300.png 254w, https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Decoding_203_Ctx-200x236.png 200w\" sizes=\"auto, (max-width: 740px) 100vw, 740px\" \/><\/div><\/div><\/div><\/div><\/div><div class=\"vc_col-sm-3 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Die Dekodierleistung sowohl f\u00fcr den Raum als auch f\u00fcr den Kontext nahm im Laufe der Tage sowohl bei den linken als auch bei den rechten K\u00f6rnerzellenpopulationen zu. Dennoch waren die Dekodierungsfehler bei den linken K\u00f6rnerzellenpopulationen immer deutlich geringer, was darauf hindeutet, dass kontextuelle Informationen von den K\u00f6rnerzellen je nach Gehirnh\u00e4lfte unterschiedlich verarbeitet werden.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"l-section wpb_row height_custom\"><div class=\"l-section-h i-cf\"><div class=\"g-cols vc_row via_flex valign_top type_default stacking_default\"><div class=\"vc_col-sm-12 wpb_column vc_column_container\"><div class=\"vc_column-inner\"><div class=\"wpb_wrapper\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><h2>Ver\u00f6ffentlichungen<\/h2>\n<\/div><\/div><div class=\"w-separator size_small\"><\/div><div class=\"w-tabs layout_ver navwidth_auto navpos_left style_default switch_click has_scrolling\" style=\"--sections-title-size:1em\"><div class=\"w-tabs-list items_4 align_none\"><div class=\"w-tabs-list-h\"><button class=\"w-tabs-item active\" aria-controls=\"content-f458\"><span class=\"w-tabs-item-title\">2021 &#8211; 2024<\/span><\/button><button class=\"w-tabs-item\" aria-controls=\"content-b66d\"><span class=\"w-tabs-item-title\">2016 &#8211; 2020<\/span><\/button><button class=\"w-tabs-item\" aria-controls=\"content-j831\"><span class=\"w-tabs-item-title\">2010 &#8211; 2015<\/span><\/button><button class=\"w-tabs-item\" aria-controls=\"content-y9d6\"><span class=\"w-tabs-item-title\">\u00dcbersichtartikel<\/span><\/button><\/div><\/div><div class=\"w-tabs-sections titles-align_none icon_chevron cpos_right\"><div class=\"w-tabs-section active\" id=\"f458\"><button aria-controls=\"content-f458\" class=\"w-tabs-section-header active\"><div class=\"w-tabs-section-title\">2021 &#8211; 2024<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-f458\" aria-expanded=\"true\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><p>Hemisphere-specific spatial representation by hippocampal granule cells. Cholvin T, Bartos M. <strong>Nature Commun<\/strong>.\u00a0 2022 Oct 20;13(1):6227.<\/p>\n<p>The hippocampus converts dynamic entorhinal inputs into stable spatial maps. Cholvin T, Hainmueller T, Bartos M. <strong>Neuron<\/strong>. 2021, 109:3135-3148.e7.<\/p>\n<\/div><\/div><\/div><\/div><\/div><div class=\"w-tabs-section\" id=\"b66d\"><button aria-controls=\"content-b66d\" class=\"w-tabs-section-header\"><div class=\"w-tabs-section-title\">2016 &#8211; 2020<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-b66d\" aria-expanded=\"false\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><div id=\"content-radd\" class=\"w-tabs-section-content\" aria-expanded=\"true\">\n<div class=\"w-tabs-section-content-h i-cf\">\n<div class=\"wpb_text_column\">\n<div class=\"wpb_wrapper\">\n<p>Ventral midline thalamus lesion prevents persistence of new (learning-triggered) hippocampal spines, delayed neocortical spinogenesis, and spatial memory durability. Klein MM, Cholvin T, Cosquer B, Salvadori A, Le Mero J, Kourouma L, Boutillier AL, Pereira de Vasconcelos A, Cassel JC. <strong>Brain Struct Funct.<\/strong> 2019, 224:1659-1676.<\/p>\n<p>Ventral midline thalamus is necessary for hippocampal place field stability and cell firing modulation. Cholvin T, Hok V, Chaillan FA, Giorgi L, and Poucet B.<strong> J Neurosci. <\/strong>2018, 38:158-172.<\/p>\n<p>Using MRI to predict the fate of excitotoxic lesions in Rats. Cholvin T, Giorgi L, Baril N, Brezun JM, Poucet B, and Chaillan FA. <strong>PLoS One.<\/strong> 2018, 13:e0200659.<\/p>\n<p>Environmental enrichment enhances systems-level consolidation of a spatial memory after lesions of the ventral midline thalamus. Ali M, Cholvin T, Muller MA, Cosquer B, Kelche C, Cassel JC, Pereira de Vasconcelos A. <strong>Neurobiol Learn Mem.<\/strong> 2017, 141:108-123.<\/p>\n<p>Dorsal hippocampus and medial prefrontal cortex each contribute to the retrieval of a recent spatial memory in rats. Cholvin T, Loureiro M, Cassel R, Cosquer B, Herbeaux K, de Vasconcelos AP, Cassel JC. <strong>Brain Struct Funct.<\/strong> 2016, 221:91-102.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div class=\"w-tabs-section\" id=\"j831\"><button aria-controls=\"content-j831\" class=\"w-tabs-section-header\"><div class=\"w-tabs-section-title\">2010 &#8211; 2015<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-j831\" aria-expanded=\"false\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><div id=\"content-nbf2\" class=\"w-tabs-section-content\" aria-expanded=\"true\">\n<div class=\"w-tabs-section-content-h i-cf\">\n<div class=\"wpb_text_column\">\n<div class=\"wpb_wrapper\">\n<p>The ventral midline thalamus contributes to strategy shifting in a memory task requiring both prefrontal cortical and hippocampal functions. Cholvin T, Loureiro M, Cassel R, Cosquer B, Geiger K, De Sa Nogueira D, Raingard H, Robelin L, Kelche C, Pereira de Vasconcelos A, Cassel JC. <strong>J Neurosci.<\/strong> 2013, 33:8772-8783.<\/p>\n<p>The ventral midline thalamus (reuniens and rhomboid nuclei) contributes to the persistence of spatial memory in rats. Loureiro M, Cholvin T, Lopez J, Merienne N, Latreche A, Cosquer B, Geiger K, Kelche C, Cassel JC, Pereira de Vasconcelos A. <strong>J Neurosci.<\/strong> 2012, 32:9947-9959.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div class=\"w-tabs-section\" id=\"y9d6\"><button aria-controls=\"content-y9d6\" class=\"w-tabs-section-header\"><div class=\"w-tabs-section-title\">\u00dcbersichtartikel<\/div><div class=\"w-tabs-section-control\"><\/div><\/button><div  class=\"w-tabs-section-content\" id=\"content-y9d6\" aria-expanded=\"false\"><div class=\"w-tabs-section-content-h i-cf\"><div class=\"wpb_text_column\"><div class=\"wpb_wrapper\"><ul>\n<li>The reuniens and rhomboid nuclei of the thalamus: A crossroads for cognition-relevant information processing? Cassel JC, Ferraris M, Quilichini P, Cholvin T, Boch L, Stephan A, Pereira de Vasconcelos A. <strong>Neurosci Biobehav Rev<\/strong>. 2021, 126:338-360.<\/li>\n<li>The reuniens and rhomboid nuclei: neuroanatomy, electrophysiological characteristics and behavioral implications. Cassel JC, Pereira de Vasconcelos A, Loureiro M, Cholvin T, Dalrymple-Alford JC, Vertes RP. <strong>Prog Neurobiol.<\/strong> 2013, 111:34-52<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section>\n<\/section>","protected":false},"excerpt":{"rendered":"Forschungsgruppe Hippocampus-Interaktionen gef\u00fchrt von Dr. Thibault Cholvin Mithilfe der In-vivo-Zweiphotonen-Kalziumbildgebung bei verhaltensgest\u00f6rten M\u00e4usen untersuchen wir, wie das Gehirn Erfahrungen in kortiko-hippocampalen Netzwerken erfasst und langfristig speichert. Kontact: thibault-cholvin@physiologie.uni-freiburg.de Forschung Wir erforschen die r\u00e4umliche Navigation und das episodische Ged\u00e4chtnis bei verhaltensgest\u00f6rten M\u00e4usen. Mithilfe der Zwei-Photonen-Kalzium-Bildgebung in vivo verfolgen wir die Aktivit\u00e4t von Neuronen \u00fcber l\u00e4ngere Zeitr\u00e4ume...","protected":false},"author":5,"featured_media":2446,"parent":1513,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2940","page","type-page","status-publish","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Dr. Thibault Cholvin - Forschungsgruppe Hippocampus-Interaktionen - Institute of Physiology, Department 1 | University of Freiburg<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/physiology-freiburg.de\/de\/forschung\/dr-thibault-cholvin-forschungsgruppe-hippocampus-interaktionen\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dr. Thibault Cholvin - Forschungsgruppe Hippocampus-Interaktionen - Institute of Physiology, Department 1 | University of Freiburg\" \/>\n<meta property=\"og:url\" content=\"https:\/\/physiology-freiburg.de\/de\/forschung\/dr-thibault-cholvin-forschungsgruppe-hippocampus-interaktionen\/\" \/>\n<meta property=\"og:site_name\" content=\"Institute of Physiology, Department 1 | University of Freiburg\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-13T19:40:07+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/physiology-freiburg.de\/wp-content\/uploads\/2023\/12\/Group_image-1024x546.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"546\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Gesch\u00e4tzte Lesezeit\" \/>\n\t<meta name=\"twitter:data1\" content=\"9\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/physiology-freiburg.de\\\/de\\\/forschung\\\/dr-thibault-cholvin-forschungsgruppe-hippocampus-interaktionen\\\/\",\"url\":\"https:\\\/\\\/physiology-freiburg.de\\\/de\\\/forschung\\\/dr-thibault-cholvin-forschungsgruppe-hippocampus-interaktionen\\\/\",\"name\":\"Dr. Thibault Cholvin - Forschungsgruppe Hippocampus-Interaktionen - Institute of Physiology, Department 1 | University of Freiburg\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/physiology-freiburg.de\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/physiology-freiburg.de\\\/de\\\/forschung\\\/dr-thibault-cholvin-forschungsgruppe-hippocampus-interaktionen\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/physiology-freiburg.de\\\/de\\\/forschung\\\/dr-thibault-cholvin-forschungsgruppe-hippocampus-interaktionen\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/physiology-freiburg.de\\\/wp-content\\\/uploads\\\/2023\\\/12\\\/Group_image.png\",\"datePublished\":\"2024-03-13T19:05:43+00:00\",\"dateModified\":\"2024-03-13T19:40:07+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/physiology-freiburg.de\\\/de\\\/forschung\\\/dr-thibault-cholvin-forschungsgruppe-hippocampus-interaktionen\\\/#breadcrumb\"},\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/physiology-freiburg.de\\\/de\\\/forschung\\\/dr-thibault-cholvin-forschungsgruppe-hippocampus-interaktionen\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\\\/\\\/physiology-freiburg.de\\\/de\\\/forschung\\\/dr-thibault-cholvin-forschungsgruppe-hippocampus-interaktionen\\\/#primaryimage\",\"url\":\"https:\\\/\\\/physiology-freiburg.de\\\/wp-content\\\/uploads\\\/2023\\\/12\\\/Group_image.png\",\"contentUrl\":\"https:\\\/\\\/physiology-freiburg.de\\\/wp-content\\\/uploads\\\/2023\\\/12\\\/Group_image.png\",\"width\":2643,\"height\":1410},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/physiology-freiburg.de\\\/de\\\/forschung\\\/dr-thibault-cholvin-forschungsgruppe-hippocampus-interaktionen\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/physiology-freiburg.de\\\/de\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Forschung\",\"item\":\"https:\\\/\\\/physiology-freiburg.de\\\/de\\\/forschung\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Dr. Thibault Cholvin &#8211; 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