{"id":3314,"date":"2023-01-31T20:41:13","date_gmt":"2023-01-31T18:41:13","guid":{"rendered":"https:\/\/physiology-freiburg.de\/sauer\/"},"modified":"2024-12-19T09:23:35","modified_gmt":"2024-12-19T08:23:35","slug":"sauer","status":"publish","type":"page","link":"https:\/\/physiology-freiburg.de\/de\/sauer\/","title":{"rendered":"Lab – PD Dr. Jonas-Frederic Sauer – Cortical Dynamics Research Group"},"content":{"rendered":"
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Cortical Dynamics Research Group<\/h1>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section>
led by<\/strong><\/h6>\n

P.D. Dr. Jonas-Frederic Sauer<\/h2>\n

We investigate the dynamics of brain circuit activity in health and disease.<\/p>\n

Contact Jonas<\/a><\/p>\n<\/div><\/div><\/div><\/div><\/div>

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Team members<\/h2>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section>

Ole Sylte
\n<\/strong><\/p>\n

Contact Ole<\/a><\/p>\n<\/div><\/div><\/div><\/div><\/div>

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SeongHee Cho
\n<\/strong><\/p>\n

Contact SeongHee<\/a><\/p>\n<\/div><\/div><\/div><\/div><\/div>

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Research<\/h2>\n

We focus on how the medial prefrontal cortex (mPFC), a brain region critical for higher cortical functions, and its downstream targets enable cognitive and emotional behaviour of mice by investigating network function with a panel of in vivo methods. First, by probing the mPFC circuitry with long-term 1-photon calcium imaging, we aim to reveal organizational principles of neocortical activities over multiple timescales. Second, using mouse models of psychiatric illness, we aim to uncover how circuit dysfunction leads to behavioural deficits. We thus seek to obtain a comprehensive understanding of the neuronal network mechanisms controlling emotional and cognitive states.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section>

Techniques<\/h2>\n<\/div><\/div>